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Program | Posters

American College Of Surgeons, Division Of Education Accreditation Statement
This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of the American College of Surgeons and the Surgical Infection Society. The American College of Surgeons is accredited by the ACCME to provide continuing medical education for physicians.

AMA PRA Category 1 Credits™
The American College of Surgeons designates this live activity for a maximum of 22 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosure Information
In compliance with ACCME Accreditation Criteria, the American College of Surgeons, as the accredited provider of this activity, must ensure that anyone in a position to control the content of the educational activity has disclosed all relevant financial relationships with any commercial interest. All reported conflicts are managed by a designated official to ensure a bias-free presentation. Please see the insert to this program for the complete disclosure list.


Program
Wednesday, April 18, 2012
12:00-13:00
Fairway Ranch
Executive Council Luncheon (By invitation)
13:00-17:00
Fairway Ranch
Executive Council Meeting (By invitation)
17:00-18:00
Fairway Ranch
Nominating Committee (By invitation)
19:00-21:30
Byron’s
Presidential Dinner (By invitation)
Thursday, April 19, 2012
07:30-10:15
Four Seasons Ballroom
ANNUAL UPDATE SYMPOSIUM:
Prevention of Surgical Site Infection: A Systematic Review of the Evidence

Welcome and Introduction
Sandra Berrios-Torres, MD and E. Patchen Dellinger, MD

Evidence-based update to the CDC/HICPAC
Guideline for prevention of surgical site infection: Developmental process
Sandra Berrios-Torres, MD

Surgical site infection prevention: Antibiotic prophylaxis and the evidence
Kamal M. F. Itani, MD

Antimicrobial bowel preparation and systemic antibiotics in elective colon surgery
Donald E. Fry, MD

Glycemic control and prevention of surgical site infection
Lillian Kao, MD

Staphylococcus aureus: Screening and decolonization
Charles E. Edmiston, MD

Prevention of surgical site infection in joint replacement surgery
Elie Berbari, MD

Teamwork and collaboration for prevention of surgical site infection
E. Patchen Dellinger, MD

Panel discussion
Sandra Berrios-Torres, MD, E. Patchen Dellinger, MD, and Arvind Nana, MD

10:15-10:30 Break
10:30-12:00
Four Seasons Ballroom
Tribute Symposium in Memory of Doctor Stephen F. Lowry
12:00-13:30
Pavilion
Lunch
13:30-16:50
Four Seasons Ballroom
PLENARY SESSION
The Art and Science of Surgical Infections (Papers 1-9)
Moderators: Pamela A. Lipsett, MD, MHPE and Robert Sawyer, MD
O1. Regulation of sepsis-induced mitochondrial respiration/biogenesis by a nitric oxide, carbon monoxide pathway.
Sean Whelan, (resident) presenting.
University of Pittsburgh.
Discussant: Michael West, MD, PhD
O2. Infectious complications following exploratory laparotomy for trauma: The case for improved antibiotic prophylaxis.
Kareem Husain, (new member) presenting.
Washington University.
Discussant: Jeffrey Claridge, MD
O3. Synthesis and efficacy of a novel phosphate-rich PEG compound (Phospho-PEG) with anti-virulence activity against multiple-antibiotic-resistant pathogens.
Alexander Zaborin, presenting.
University of Chicago.
Discussant: Donald E. Fry, MD
O4. Can surgical site infection after joint arthroplasty be reduced?
Mayank Taneja, presenting.
Rothman Institute, Thomas Jefferson University.
Discussant: E. Patchen Dellinger, MD
O5. Endothelial TLR4 signaling is responsible for intestinal ischemia in the pathogenesis of necrotizing enterocolitis via its effect on the expression of microvascular tone regulators: eNOS and endothelin-1.
Ibrahim Yazji (resident), presenting.
University of Pittsburgh.
Discussant: Henri R. Ford, MD, MHA
O6. Chest x-ray report language is incongruous with quantitative culture results in ventilator-associated pneumonia.
Heather Evans, presenting.
University of Washington.
Discussant: Addison K. May, MD
O7. Bacterial and mitochondrial DNA assays distinguish sepsis from SIRS in primates.
Carl Hauser, presenting.
Beth Israel Deaconess Hospital/Harvard Medical School.
Discussant: Philip S. Barie, MD, MBA
O8. Multi-drug resistance does not influence mortality in critically ill patients with Acinetobacter infections.
Claire Murphy, presenting.
The Ohio State University.
Discussant: Nicholas Namias, MD, MBA
O9. Remote ischemic preconditioning prevents lung and liver injury following hemorrhagic shock/resuscitation.
Chung Ho Leung, presenting.
St. Michaels-Toronto.
Discussant: Timothy R. Billiar, MD
17:00-18:00
Brazos
SIS Antibiotic Duration Study-Robert Sawyer, MD
17:30-18:15
Boardroom
Surgical Infection Editorial Reception (By Invitation)
18:15-19:00
Brazos
SIS Foundation Board Meeting (By Invitation)
18:30-20:30
Pool Terrace
Welcome Reception
 
Friday, April 20, 2012
07:00-08:00
Pavilion
Committee Meetings
(Attendance mandatory for committees)
08:00-9:45
Amphitheater
PARALLEL SESSION I
Fundamental Mechanisms of Surgical Infection (Papers 10-15)
Moderators: William G. Cheadle, MD and Ori Rotstein, MD
O10. Cues present at anastomotic leak sites induce a stable mexT mutation in Pseudomonas aeruginosa causing enhanced tissue-destroying capacity.
Benjamin Shoga (resident), presenting.
University of Chicago.
Discussant: Brian Zuckerbraun, MD
O11. Interleukin (IL)-25 improves innate and acquired immunity during parenteral nutrition.
Aaron Heneghan, presenting.
University of Wisconsin-Madison.
Discussant: Jared Huston, MD
O12. Oncostatin M (OSM) receptor deficiency provides a survival advantage in a septic shock model.
Pang Young (resident), presenting.
University of Alberta.
Discussant: John C. Marshall, MD
O13. Neurotransmitters modulate expression and release of cold-inducible RNA-binding protein (CIRP), a proinflammatory mediator in macrophages.
Weng-Lang Yang (new member), presenting.
Hofstra North Shore-LIJ School of Medicine.
Discussant: William G. Cheadle, MD
O14. Age and autophagy in sepsis-induced acute kidney injury: A role for the calcium/calmodulin-dependent protein kinases.
Gina Howell (resident), presenting.
University of Pittsburgh.
Discussant: Rachel Khadaroo, MD, PhD
O15. The ApoE4 isoform is associated with an increased inflammatory response in humans after in vivo endotoxin challenge.
Stephen Gale, presenting.
Robert Wood Johnson Medical School-University of Medicine and Dentistry of New Jersey.
Discussant: Alfred Ayala, PhD
08:00-10:30
Four Seasons Ballroom
PARALLEL SESSION II
Clinical Investigations in Surgical Infection (Papers 16-21)
Moderators: John C. Marshall, MD and Mark Malangoni, MD
O16. The burden of unnecessary empiric antibiotic therapy in suspected ventilator-associated pneumonia.
Jeremy Thompson, presenting.
Vanderbilt University.
Discussant: Charles Adams, MD
O17. Re-defining the clinical pulmonary infection score (CPIS) for Trauma Patients.
George DeBusk (resident), presenting.
Brown University.
Discussant: Lillian Kao, MD
O18. Do narcotics have an impact on the presence of Pseudomonas infections in the ICU?
Sandra Swoboda, presenting.
The Johns Hopkins University.
Discussant: Soumitra R. Eachempati, MD
O19. Acute kidney injury (AKI) is associated with early cytokine dysregulation after trauma.
Azra Bihorac (new member), presenting.
University of Florida and University of Washington.
Discussant: David Efron, MD
O20. Procalcitonin concentration (PCT) is associated with severity of sepsis in critically ill surgical patients (CrISPs).
Vanessa Ho (resident), presenting.
Weill Cornell Medical College.
Discussant: Therese Duane, MD
O21. Diagnosis of infection after trauma splenectomy: It’s about the lack of platelets and not the white blood cell count.
Aman Banerjee (resident), presenting.
MetroHealth Medical Center/Case Western Reserve University.
Discussant: David Blake, MD
10:00-10:15 Break - Visit the Exhibits
10:15-11:15
Four Seasons Ballroom
William A. Altemeier Memorial Lecture
Colon Cancer: Do Alpha-Bugs Lead the Charge?
Cynthia L. Sears, MD
11:15-12:15
Four Seasons Ballroom
Surgical Infection Society Presidential Address
“I am Not a Scientist”
Robert G. Sawyer, MD
12:00-13:30
Pavilion
LUNCHEON SYMPOSIUM
(Industry-sponsored; not part of scientific program)
13:30-15:45
Amphitheater
PARALLEL SESSION III
Understanding the Host Response to Surgical Infection (Papers 22-29)
Moderators: Nicholas Namias, MD and Alfred Ayala, PhD
O22. Neuregulin-4 protects intestinal cells from NEC-inducing bacteria by reduced apoptosis without promotion of cell restitution.
Shannon Castle (new member, resident), presenting.
Children's Hospital, Los Angeles.
Discussant:
O23. Dysregulation of miR-142-3p, -146, -299, and-200c downregulates HMGB1 and induces microbial tolerance in a novel model of chronic peritonitis.
Ziad Kanaan (resident), presenting.
University of Louisville.
Discussant: Michael A. West, MD, PhD
O24. Commensal bacteria play a protective role in mediating mortality from pneumonia-induced sepsis.
Benyam Yoseph, presenting.
Emory University.
Discussant: John C. Alverdy, MD
O25. A dampened inflammatory response in critically ill geriatric patients is essential to survival.
Mary Ottinger (resident), presenting.
Brown University.
Discussant: John A. Mannick, MD
O26. Changes in leukocyte expression of Ecrg4 following burns: An immunosurveillance marker?
Nicole Lopez (new member, resident), presenting.
University of California, San Diego.
Discussant: Marc Jeschke, MD
O27. The role of T regulatory cells in mesenchymal stromal cell (MSC)-mediated wound healing.
Kristin Cook (resident), presenting.
University of Medicine and Dentistry of New Jersey-New Jersey Medical School.
Discussant: Lomas-Neiras, MD
O28. Increased elderly T cell co-inhibitory receptor expression & SHP-1 activation depress T cells increasing infections.
Gautam Bandyopadhyay (new member), presenting.
University of Rochester.
Discussant: Ori Rotstein, MD
O29. Evolutionary dynamics of anastomotic leak: Investigation of virulent phenotype switching in Pseudomonas aeruginosa with an agent-based model.
Jordan Stern (resident), presenting.
The University of Chicago.
Discussant: Daithi Heffernan, MD
13:30-16:00
Four Seasons Ballroom
PARALLEL SESSION IV
Outcomes Studies in Surgical Infection (Papers 30-37)
Moderators: Lena M. Napolitano, MD and Addison K. May, MD
O30. Reduction in Acinetobacter infections associated with reduction of environmental contamination of a trauma/burn intensive care unit (ICU).
L. Sylvia Munoz-Price, presenting.
University of Miami.
Discussant: Heather L. Evans, MD
O31. Burn-induced inflammatory response in adipose tissue.
Celeste Finnerty (new member), presenting.
University of Texas Medical Branch/Shriners Hospitals for Children.
Discussant: Basil A. Pruitt Jr., MD
O32. Admission serum procalcitonin concentration (PCT) diagnoses sepsis accurately in a surgical intensive care unit (SICU) patient population.
Peter McWhorter (resident), presenting.
Weill Cornell Medical College.
Discussant: Donald E. Fry, MD
O33. Examination of the bacterial microbiome in bronchoalveolar lavage samples from trauma patients utilizing next-generation sequencing technology.
Ryan Huebinger (new member), presenting.
University of Texas-Southwestern.
Discussant: Gary An, MD
O34. Mortality associated with ventilator-associated pneumonia (VAP) has decreased over time.
Laura Rosenberger (resident), presenting.
University of Virginia.
Discussant: Martin Croce, MD?
O35. The differing microbiologic profile of ventilator associated pneumonia (VAP) in geriatric versus young trauma patients.
Andrew Stephan (new member), presenting.
Brown University.
Discussant: Lewis Kaplan, MD
O36. Does negative pressure therapy reduce surgical site infections following contaminated ventral hernia repair?
David Krpata (resident), presenting.
Case Western Reserve University.
Discussant: Kamal Itani, MD
O37. Outcomes and predictors of surgical site infection (SSI) in stoma reversal.
Jennifer Moffett (resident), presenting.
Baylor College of Medicine/Rice University.
Discussant: Jose Prince, MD
16:00-17:20 POSTER SESSION (Posters 1 - 58)
Basic and Clinical Studies in Surgical Infection

Session 1: Microbiology, Biochemistry and Antibiotic Use
Co-Moderators: Matthew Rosengart, M.D., Gautam Bandyopadhyay, Ph.D., Kelly Hogan, Pharm.D.

Session 2: Surgical and Other Therapies
Co-Moderators: Greg Beilman, M.D., Samir Awad, M.D., Jose Prince, M.D.

Session 3: Surgical Site and Skin/Soft Tissue Infections
Co-Moderators: Kamal Itani, M.D., Lewis Kaplan, M.D., Jeffrey Bailey, M.D.

Session 4: Other Infections
Co-Moderators: Phil Barie, M.D, Heather Evans, M.D., Alicia Mohr, M.D.

Session 5: Outcome and Risk Factor Analyses
Co-Moderators: Lillian Kao, M.D., Thomas Z. Hayward, III, M.D., Sandra Swoboda, R.N., M.S.

17:30-18:30
Amphitheater
Annual Business Meeting
Presiding: Pamela A. Lipsett, MD, MHPE
(Members only)
19:00-20:00
Foyer
Reception
20:00-22:00
Four Seasons Ballroom
Awards Banquet
 
Saturday, April 21, 2012
07:00-08:00
TBA
Executive Council Meeting (By invitation)
08:00-09:00 SPECIAL CLINICAL SYMPOSIUM:
Unique Infections in the Military Operational Environment
Co-Moderators: COL Greg Beilman, MD and COL David Blake, MD

Prevention and treatment of combat-related infections
CDR Carlos Rodriguez, MD

Infection control in a deployed setting
COL Duane Hospenthal, MD

Utilizing a trauma systems approach to prevent infectious complications in combat casualty care
COL Jeffrey Bailey, MD

Panel discussion

09:00-11:00
Four Seasons Ballroom
COMBINED SESSION I
Mechanistic Insights into the Development of Surgical Infection (Papers 38-44)
Moderators: John C. Alverdy, MD and Edwin A. Deitch, MD
O38. Cholinergic signaling in the gut: A novel mechanism in barrier protection through activation of enteric glial cells.
Gerald Cheadle, presenting.
University of California, San Diego.
Discussant: Jared Huston, MD
O39. Sepsis-induced cardiac mitochondrial deficiency involves altered mitochondrial localization of tyrosine kinase cSrc and tyrosine phosphotase Shp2.
Qun Zang, presenting.
University of Texas-Southwestern.
Discussant: Carl Hauser, MD
O40. Investigating the dynamics of bacterial virulence in necrotizing enterocolitis with a multi-scale agent-based model.
Moses Kim, presenting.
The University of Chicago.
Discussant: Matthew Rosengart, MD
O41. Bacterial diversity in formula-fed vs. breast-fed rats and its possible role in susceptibility to necrotizing enterocolitis (NEC).
Brandon Bell, presenting.
Children's Hospital, Los Angeles.
Discussant: John Alverdy, MD
O42. Addition of proanthocyanidins to intra-gastric elemental nutrition stimulates intestinal goblet cell size and function.
Joseph Pierre, presenting.
University of Wisconsin, Madison.
Discussant: John Mazuski MD, PhD
O43. Shock/sepsis-induced neutrophil infiltration and mortality is mediated by ngiopoietin (Ang)-2.
Joanne Lomas-Neira, presenting.
Brown University.
Discussant: Philip Efron, MD
O44. Hepatic apoptosis and liver dysfunction post-burn is mediated by c-Jun N-terminal kinase-2.
Alexandra Smith, presenting.
Sunnybrook Health Science Center.
Discussant: Jeffrey Upperman, MD
11:00-11:15 Break – Visit the Exhibits
11:15-11:30 FELLOWSHIP AWARD RECIPIENT PRESENTATIONS
Moderator: Philip S. Barie, MD, MBA

The role of CaMK in the regulation of autophagy and sepsis
Gina Howell, MD, University of Pittsburgh.
Mentor: Matthew Rosengart, MD, MPH

Mediators of endothelial cell dysfunction in the development of shock-induced acute lung injury
Joanne Lomas-Neira, MS, PhD, Brown University.

11:30-13:30
Four Seasons Ballroom
COMBINED SESSION II
Basic Science and Clinical Investigations (Papers 45-52)
Moderators: Jeffrey Claridge, MD and Ping Wang, MD
O45. Surgeons don't listen: Evaluation of compliance with antimicrobial stewardship program (ASP) recommendations.
Therese M. Duane, presenting.
Virginia Commonwealth University.
Discussant: Joseph Solomkin, MD
O46. Anti-inflammatory drug discovery in vivo: Use of the zebrafish to screen compounds for their ability to inhibit neutrophil infiltration.
Filip Miscevic, presenting.
St. Michaels-Toronto.
Discussant: John Davis, MD
O47. The use of e-test minimum inhibitory concentration (MIC) values to determine vancomycin treatment failures in a surgical ICU population.
Jonathon Pouliot, presenting.
Vanderbilt University.
Discussant: Greg Beilman, MD
O48. The invariant natural killer T-cell (iNKT) response is enhanced in critically ill septic geriatric patients.
Daithi Heffernan, presenting.
Brown University.
Discussant: Carol Miller-Graziano, PhD
O49. Intravenous immunoglobulin (IVIG) does not confer protective immunity against infections in deceased donor kidney recipients.
Avinash Agarwal, presenting.
University of Virginia.
Discussant: Ping Wang
O50. The intestinal mucus layer is a critical but unrecognized component of the gut barrier.
Jordan Fishman, presenting.
University of Medicine and Dentistry of New Jersey-New Jersey Medical School.
Discussant: Olga Zaborina, PhD
O51. How much do antibiotics help? A meta-analysis of outcome erom appendix-derived peritonitis (PAP) before antibiotics.
Xiuwen Wu, presenting.
Nanjing University.
Discussant: Lena M. Napolitano, MD
O52. TNF-? Nco1 polymorphism and sepsis susceptibility in surgical patients.
Kavita Baghel (new member, resident), presenting.
Chatrapatti Sahuji Maharaj Medical Univesity, Lucknow, India.
Discussant: Joseph P. Minei, MD
13:30 Adjournment


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