Microbial Profile and Antibiotic Sensitivity in Obstructive Jaundice: Insights from a Single-Center Study

Authors:
Adianto Nugroho, Aditomo Widarso, Anti Dharmayanti, Hana Ayu Shafira, Indah Jamtani, Rofi Y Saunat

Body of Abstract:
Background. Biliary obstruction poses a significant risk of biliary tract infections, warranting prompt and effective antibiotic administration. Empiric antibiotic selection necessitates a comprehensive understanding of the microbial profile. Our study comprehensively describes the microbiology profile of bile culture in biliary obstructive patients.
Methods. A cross-sectional descriptive study was held with data gathered from medical records in our single institution from November 2020 – December 2021 and January – September 2024. Patients’ characteristics, jaundice etiology, bile culture results, and antibiotic resistance were studied.
Results. Among 45 patients that had been analyzed, we found that the most microorganisms found in positive bile culture were gram-negative bacteria, with Escherichia coli and Klebsiella pneumonia being the most found. Two cases had Candida sp. The bacteria were most resistant to penicillin-group antibiotics and most sensitive to carbapenem, amikacin, and tigecycline.
Conclusions. The most prevalent microbes discovered in biliary tract obstruction were gram negative bacteria, with penicillin-group antibiotics being the most resistant antibiotics. Administering the right antibiotics that fit the microorganism profile is critical to prevent antibiotic resistance.