Tunable Sequential Drug Delivery System for Management of Non-healing Infected Wound

Author(s):
Jinjian Huang; Jianan Ren

Background:

Treatment of non-healing infected wound is an arduous task in clinical practice.

Hypothesis:

Early antibacterial strategy and subsequent promotion of granulation tissue growth facilitate to cure the wound.

Methods:

We fabricated a sequential drug delivery system by incorporation of an injectable hydrogel with porous PLGA microspheres. Vancomycin was linked to the injectable hydrogel via a reversible schiff ‘s base reaction, and VEGF were encapsulated into PLGA microspheres.

Results:

The results demonstrated that releasing file of vancomysin was pH-dependent and VEGF’s file was regulated by pore size of PLGA microspheres. The duration of VEGF release was longer than vancomycin. This system was valid to inhibit bacteria growth and accelerate vein endothelial cell proliferation in vitro. In animal models, it was effective to manage non-healing infected wounds by reducing inflammation and promoting angiogenesis.

Conclusions:

In conclusion, the sequential delivery system is promosing to be applied in management of non-healing infected wound.